FIGURE 2.

The inhibition upon the voltage-sensing phosphatases (VSPs) activation. (A) TRPC6 currents induced by a DAG analog (OAG) are transiently inhibited by Dr-VSP activation (Imai et al., 2012). (B) Inhibitory effects of VSPs on TRPC6 and KCNQ2/3 channels. Data for TRPC6 channels are from Imai et al. (2012). Parenthesizes indicate values for KCNQ2/3 channels (Falkenburger et al., 2010). *Unpublished data from experiments in which equal amounts of plasmid harboring cDNA encoding Ci-, Dr-, or Gg-VSP, and TRPC6 were co-transfected into HEK293 cells. Currents were evoked using 50 μM OAG.