Table 2.
Treatment-related toxicities, grade 2 or above
| Toxicity | Grade 2 | Grade 3 | Grade 4 | Total |
|---|---|---|---|---|
| Hematologic | ||||
| Thrombocytopenia | 0 | 1 | 0 | 1 |
| Leukopenia | 0 | 2 | 0 | 2 |
| Neutropenia | 1 | 0 | 0 | 1 |
| Lymphopenia | 1 | 3 | 1 | 5 |
| Dermatologic | ||||
| Acne | 4 | 0 | 0 | 4 |
| Desquamation | 3 | 0 | 0 | 3 |
| Pruritis | 0 | 1 | 0 | 1 |
| Photosensitivity | 0 | 1 | 0 | 1 |
| Hand-foot rash | 0 | 1 | 0 | 1 |
| Endocrine | ||||
| Hypertriglyceridemia | 0 | 1 | 0 | 1 |
| Hyperglycemia | 1 | 0 | 0 | 1 |
| Hypophosphatemia | 1 | 3 | 0 | 4 |
| Constitutional | ||||
| Fatigue | 4 | 2 | 0 | 6 |
| Gastrointestinal | ||||
| Anorexia | 1 | 0 | 0 | 1 |
| Nausea | 1 | 0 | 0 | 1 |
| Diarrhea | 1 | 0 | 0 | 1 |
| Colitis | 0 | 1 | 0 | 1 |
| Liver function | ||||
| Elevated AST/SGOT | 0 | 1 | 0 | 1 |
| Vascular | ||||
| Thrombosis/embolism | 0 | 0 | 2 | 2 |
| Other | ||||
| Proteinuria | 1 | 0 | 0 | 1 |
| Prolonged QTc interval | 0 | 1 | 0 | 1 |
| Headache | 0 | 1 | 0 | 1 |
| Insomnia | 1 | 0 | 0 | 1 |
Grade 2 toxicities listed are those that were deemed probably or definitely related to study medications by treating physicians
Grade 3 and 4 toxicities listed are those that were deemed possible, probable or definitely related to study medications by treating physicians