Table 2.
Samples Genotyped for A673T (rs63750847) by TaqMan Assaya
| Characteristic | Cohort
|
|||||
|---|---|---|---|---|---|---|
| United States
|
Sweden
|
|||||
| ACTb | Cache County Study on Memory Health and Aging | Total White Individuals | Cohort 1 | Cohort 2 | Total Swedish Individuals | |
| Samples, No. (A673T heterozygotes, No.) | ||||||
|
| ||||||
| Cases | 498 (1) | 506 (0) | 1004 (1) | 298 (0) | 564 (0) | 862 (0) |
|
| ||||||
| Controls | 1953 (1) | 3838 (1) | 5791 (2) | 220 (0) | 487 (3) | 707 (3) |
|
| ||||||
| Dementia, otherc | 138 (0) | 383 (0) | 521 (0) | 0 | 0 | 0 |
|
| ||||||
| Total | 2589 (2) | 4727 (1) | 7313 (3) | 518 (0) | 1051 (3) | 1569 (3) |
|
| ||||||
| Male, No. (%) | ||||||
|
| ||||||
| Cases | 34.2 | 32.3 | 36.9 | 41.7 | ||
|
| ||||||
| Controls | 43.5 | 41.7 | 25.0 | 72.1 | ||
|
| ||||||
| Age, mean (SD), y | ||||||
|
| ||||||
| At onset for cases | 84.1 (5.6) | 82.4 (6.9) | 75.7 (12.9) | |||
|
| ||||||
| At sampling for cases | 76.4 (10.7) | |||||
|
| ||||||
| At last examination for controls | 81.2 (7.0) | 79.8 (6.3) | 98.0 (1.5) | |||
|
| ||||||
| At sampling for controls | 62.7 (10.7) | |||||
|
| ||||||
| Cohort type | Prospective cohort | Prospective cohort | Case-control | Case-control | ||
Abbreviation: ACT, Adult Changes in Thought.
a
Life Technologies.
b
Includes ACT samples genotyped using the exome array and an additional 364 cases, 1344 controls, and 117 other dementias. The two A673T variants are the same as in Table 1.
c
Includes vascular dementia, mixed dementias, and other rare forms of dementia.