Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 11;9:2. doi: 10.3389/fncir.2015.00002

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Fields and Mitchell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Metaplasticity in AIH induced pLTF and carotid (chemo)sensory long-term facilitation (csLTF) following preconditioning with chronic intermittent hypoxia (CIH). On left, time controls (TC) are without AIH, and no pLTF is observed. In contrast, AIH elicits pLTF in rats pretreated with both normoxia (Nx) and CIH (*p < 0.05 vs. TC). However, AIH-induced pLTF is greater in rats preconditioned with CIH vs. Nx (^#p < 0.05 vs. Nx), demonstrating meta-plasticity in pLTF (data from Ling et al., 2001). On right, sensory recordings of the carotid sinus nerve reveal no csLTF in rats exposed to AIH following Nx preconditioning (post 60 min). However, after CIH preconditioning, robust csLTF is observed, revealing a form of plasticity not present in normal rats (i.e., metaplasticity; data from Peng and Prabhakar, 2003).