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. 2015 Feb 11;6:40. doi: 10.3389/fgene.2015.00040

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Copyright © 2015 Merelli, Tordini, Drocco, Aldinucci, Liò and Milanesi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hi–C for Cytogenetic application. Comparison of FISH data and Hi–C information for the cytogenetic analysis of translocation in leukemia. In panel (A) the neighborhood graph of the genes ABL1 and BCR generated from the GM06990 cell line (Lieberman-Aiden experiment SRA:SRR027956) is presented. The graph shows that in normal cells the genes are not directly in contact since other genes are placed between them. In panel (B) the neighborhood graph of the genes ABL1 and BCR from the K562 cell line (Lieberman-Aiden experiment SRA:SRR027962) is presented. The graph shows that in cancer cells the genes are closer one to the other, which is a preliminary evidence of a possible translocation.