Table 2.
List of SNPs Included in the GWAS Previously Associated With HIV-1 Disease Progression or Presence of X4-D/M Virus Determined by Phenotypic Assay
| OR (P value) for Association Analysis by Ancestry |
|||||||
|---|---|---|---|---|---|---|---|
| SNPa | Gene | Marker | Prior Reported Effect | European (n = 266) | African American (n = 209) | Hispanic (n = 118) | Meta-Analysisa (n = 593) |
| rs333 | CCR5 | Δ32 | Decreased susceptibility [22] | 1.45 (0.252) | 4.03 (0.213) | 1.9 (0.548) | 1.59 (0.120) |
| rs1799987 | CCR5 | P1 | Fast progression [20] | 0.92 (0.677) | 0.79 (0.309) | 0.76 (0.375) | 0.84 (0.205) |
| rs1800023 | CCR5 | A676G | Slow progression [19] | 1.04 (0.845) | 1.00 (1.000) | 0.66 (0.224) | 0.94 (0.674) |
| rs1800024 | CCR5 | C927T | Slow progression [19] | 0.99 (0.976) | 1.15 (0.575) | 0.82 (0.581) | 1.02 (0.908) |
| rs2734648 | CCR5 | G280T | Slow progression [19] | 1.13 (0.530) | 0.84 (0.440) | 0.81 (0.510) | 0.96 (0.758) |
| rs1799988 | CCR5 | T627C | Slow progression [19] | 1.05 (0.795) | 0.84 (0.384) | 0.67 (0.183) | 0.89 (0.353) |
| rs1799864 | CCR2 | V64I | Slow progression [7] | 0.97 (0.945) | 1.03 (0.897) | 0.84 (0.624) | 0.97 (0.852) |
| rs1801157 | SDF1 | G801A (3′A) | Fast progression (previously associated with X4 virus) [18] | 1.17 (0.506) | 0.58 (0.241) | 0.81 (0.642) | 0.97 (0.888) |
Abbreviations: D/M, dual- or mixed-tropic virus populations; GWAS, genome-wide association studies; HIV, human immunodeficiency virus; OR, odds ratio; SDF1, stromal cell-derived factor 1, a CXCR4 ligand; SNP, single-nucleotide polymorphism.
a Association data combined across groups using inverse-variance weighted meta-analysis.