Figure 1.

Cerebrospinal fluid levels of (1→3)-β-d-glucan (BDG) by diagnosis and change with antifungal therapy. Boxplot for log₂ BDG concentration by meningitis diagnosis, and the effect of induction therapy on BDG concentrations in patients with cryptococcal meningitis. The median BDG level was below the assay negative cutoff value of 60 pg/mL (dotted dashed line) in meningitis patients without cryptococcosis (white box). The median BDG levels in cryptococcal meningitis patients (gray boxes) was above the assay positive cutoff value of 80 pg/mL (dashed line) at diagnosis, but it rapidly normalized with induction therapy.