TABLE 3 .
Relationship between (i) Fc N-glycosylation features and serum mediators and (ii) clinical severitya
| Predictors | OR | 95% CI | β | P value |
|---|---|---|---|---|
| Univariate models | ||||
| IgG1 Fc Gal | 0.11 | 0.02–0.52 | −2.24 | 0.006 |
| IgG1 Fc Sial | 0.35 | 0.16–0.78 | −1.05 | 0.010 |
| IgG2 and -3 Fc Sial | 0.24 | 0.09–0.64 | −1.43 | 0.005 |
| IL-6 | 2.98 | 1.74–5.12 | 1.09 | <0.001 |
| TNF-α | 3.11 | 1.77–5.45 | 1.13 | <0.001 |
| IFN-γ | 2.31 | 1.37–3.91 | 0.84 | 0.002 |
| IL-17 | 3.87 | 1.65–9.07 | 1.35 | 0.002 |
| IL-10 | 2.41 | 1.50–3.87 | 0.88 | <0.001 |
| CRP | 11.38 | 3. 23–40.0 | 2.43 | <0.001 |
| Multivariate model | ||||
| IgG1 Fc Gal | 0.12 | 0.02–0.63 | −2.12 | 0.012 |
| IL-6 | 2.60 | 1.49–4.56 | 0.96 | 0.001 |
| CRP | 9.05 | 2.45–33.5 | 2.20 | 0.001 |
a
Significant statistical associations of predictors with categories of severity were evaluated by using univariate and multivariate ordinal logistic regression models. CI, confidence interval; Gal, level of galactosylation; OR, odds ratio; Sial, level of sialylation; β, estimative coefficient.