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Rifampin resistance carries a fitness cost. Bars show the competitive fitness of rifampin-resistant mutants (mean ± SE; n = 3) relative to that of the rifampin-sensitive ancestral strain, as determined by competition assays in rifampin-free M9KB culture medium. On average, rifampin resistance mutations reduce fitness by 15.8%. Individual mutations that are associated with significant fitness costs, as determined by Dunnett’s test, are shown with an asterisk (*, P < 0.05).
