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. 2015 Feb 11;6:18. doi: 10.3389/fgene.2015.00018

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Copyright © 2015 O’Rourke, FitzGerald, Traverse and Cooper.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of biofilm regulation in Burkholderia cenocepacia building upon the Wsp model in Pseudomonas. Surface signaling at WspA leads to a phosphorylation cascade, activating WspHRR. W mutants in this study possessed mutations in wspA and wspE, leading to autoinduction of this process; S mutants possessed secondary mutations that also clustered in wsp or in Bcen2424_1436, as highlighted by symbols in the legend. We predict that the DNA-binding response-regulator Bcen2424_1436 is phosphorylated by WspHRR, which stimulates biofilm production by transcriptional activation. As part of a predicted two-component system, the Bcen2424_1436 protein also likely receive signals from a transmembrane sensor histidine kinase, Bcen2424_1438, which has conserved domains matching a periplasmic domain, a PAS fold, and a HATPase domain.