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. 2009 Jul 8;2009(3):CD002759. doi: 10.1002/14651858.CD002759.pub2

Topp 2002.

Methods RCT 
 Method of randomisation: not reported 
 Assessor blinding: not reported 
 Participant blinding: not reported 
 Loss to follow‐up: 0 
 Intention‐to‐treat analysis: N/A 
 Post‐program follow up: no
Participants Location: USA 
 N = 35 
 Sample: adults with knee OA 
 Age: mean = 65.57 years (SD = 1.82) estimated 
 Inclusion criteria: knee pain due to OA (based on WOMAC); physician validated the knee pain and the diagnosis of OA 
 Exclusion criteria: had any contraindications for exercise, including a history of uncontrolled angina, cardiomyopathy severe enough to compromise cardiac functioning, electrolyte or metabolic disturbances, disabilities that prohibited resistance training of the lower extremities, or if they were currently taking nitrates, digitalis, or phenothiazine. Individuals were also excluded if they were currently participating in an organized exercise program or exercised more than 1 hour per week.
Interventions PRT versus control 
 1. PRT 
 Type of Ex: 6 LL for 30 minutes 
 Equipment: Thera‐Band elastic bands 
 Intensity: self exertion of mild fatigue after 8RM 
 Frequency: Ex3 (2 at home 1 at gym) 
 Reps/Sets: increasing reps and sets every week and then reached 12 reps/3sets at week 9 to 16 
 Duration: 16 weeks 
 Setting: home and gym 
 Supervision: provided in the gym 
 Adherence: each participant had exercise log, but results were not reported 
 2. Control Group: no intervention
Outcomes WOMAC 
 Knee pain 
 Stair climbing 
 Down and up off the floor 
 Comments on adverse events: no
Notes Calculated SDs from reported SEMs
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear