| Methods |
RCT trial with 4 groups: PRT alone, growth hormone treatment alone, PRT and growth hormone treatment and control. Only PRT alone and control are included in this review
Method of randomisation: not reported
Assessor blinding: no
Participant blinding: no
Loss to follow‐up: not reported
Intention‐to‐treat analysis: no
Post‐program follow up: no |
| Participants |
Location: USA
N = 16 in PRT and control
Sample: frail older people
Age: mean 71.3 years (SD 4.5)
Inclusion criteria: frail which was defined as scoring between 12 and 28 on Reuben's Physical Performance Test;
Exclusion criteria: medical conditions (cancer, heart disease, diabetes, recent fracture, carpal tunnel syndrome) that would interfere with administration of growth hormone or the performance of regular exercise 3 times per week; did not expect to spend a year in Rhode Island; their doctor convinced them not to participate for medical reasons or otherwise; unwilling to inject the drug and be randomised to exercise or no exercise |
| Interventions |
PRT versus control
1. PRT
Type of Ex: 11 exercises (UL & LL)
Equipment: ankle and wrist weights and exercise equipment
Intensity: increased from 20% to 95% of 1 RM‐most training was at high intensity
Frequency: Ex3
Reps/Sets: 8/3
Duration: 25 weeks
Setting: gym (in study facilities or local community centers)
Supervision: Full
Adherence: not reported
2. Control Group: not reported |
| Outcomes |
Strength (isokinetic dynamometry)
Physical Performance Test (PPT)
Comments on adverse events: no |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
