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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Magn Reson Imaging. 2014 Dec 5;33(3):262–269. doi: 10.1016/j.mri.2014.11.002

Table 1.

Main demographic, clinical and MRI derived characteristics of patients and healthy controls.

Healthy Controls CIS RRMS SPMS
N(Females) 103 (55) 9 (7) 87 (67) 12 (6)
Age (years)
Mean ± S.D.
Median [Range]
37.0 ± 10.5
35.9 [20.7-61.8]
39.2 ± 14.7
40.2 [20.8-50.6]
42.6 ± 9.9
44.6 [22.0-63.1]
54.2 ± 9.0
56.1 [35.4-62.9]
Disease Duration
(years) 		not applicable 2.8 ± 3.2
1.3 [0.2-8.8]		 11.0 ± 9.2
10.0 [0.1-36.8]		 18.4 ± 9.3
18.9 [1.8-30.9]
EDSS not applicable 0.4 ± 0.8
0 [0-2]		 1.7 ± 1.6
1.5 [0-6.5]		 4.4 ± 1.5
4.5 [2-6.5]
Lesion Load(mL) No lesions 2.21 ± 2.74
1.34 [0.15-8.16]		 12.35 ± 11.71
7.41 [0.18-4.8]		 25.0 ± 14.4
26.8 [7.0-59.3]
LV Volume (mL)
LV-to-ICV volume
Percentage 		12.07 ± 5.70
0.78 ± 0.36		 15.45 ± 9.95
1.02 ± 0.59
P (HC, CIS) = 0.08		 18.75 ± 9.52
1.29 ± 0.65
P (RRMS, HC) ~
3×10−10 		35.52 ± 14.30
2.47 ± 1.04
P (SPMS, HC) ~5×10−21
LV
Mean Diffusivity
(×10−3 mm2 sec−1) 		2.79 ± 0.10 2.78 ± 0.10
P (HC , CIS) =
0.6		 2.85 ± 0.10
P (RRMS > HC)
= 0.0001		 2.97 ± 0.08
P (SPMS > HC) ~
4×10−8

The MRI derived measures include the lateral ventricle volume cerebrospinal fluid volume (mL), and LV-to-intracranial volume percentage (LVv/ICV (x100%), and corresponding average LV diffusivity.

Abbreviations: CIS = clinically isolated syndrome; RRMS = Relapsing-remitting multiple sclerosis; SPMS = Secondary progressive multiple sclerosis; HC = healthy controls.