TABLE I.
Reference | Pts (n) | Paclitaxel | Radiotherapy dosing (cGy) | Toxicity | |
---|---|---|---|---|---|
| |||||
Dose (mg/m2) | Schedule | ||||
Elmongy et al., 199943 | 32 | 175–225 | Every 3 weeks | 5040–6300 | Grade 3 skin toxicity: 9 |
Bellon et al., 200044 | 8 | 20–35×4 days | Every 3 weeks | 4680–5040 | Acute skin toxicity requiring |
9 | 135–175 | Every 3 weeks | plus boost | delay exceeding 5 days: 6 | |
Taghian et al., 200145 | 7 | 175 | Every 3 weeks | 4000–4600 | Pneumonitis: 3 of the 21 |
14 | 60–100 | plus 600–2000 boost | |||
Hanna et al., 200246 | 20 | 175 | Every 3 weeks ×3 |
bcs: 4500 plus 1600 mast: 5040 plus 1000 |
Grade 3 skin toxicity: 7 Pneumonitis: 4 |
Formenti et al., 200347 | 44 | 30 | Twice weekly | 4500 plus 1800 | Grade 3 skin toxicity: 3 |
Kao et al., 200548 | 16 | 20–30×4 days | Every 2 weeks | 6000 | Greater than grade 3 skin toxicity: |
17 | 80 | Weekly | 8 of the 33 | ||
Burstein et al., 200649 | 16 | 60 | Weekly | mast: 4500 plus 400–1000 | Pneumonitis in 3 of 16 |
24 | 135–175 | Every 3 weeks | bct: 4500 plus 1000–1600 | ||
Chakravarthy et al., 200650 | 38 | 30 | Twice weekly | 4500 plus 1400 | Skin toxicity: 1 |
Chen et al., 201051 | 44 | 175 | Every 3 weeks | 3960 plus 1400 | Grade 3 skin toxicity: 2 |
Pts = patients; bcs = breast-conserving surgery; mast = mastectomy; bct = breast-conserving therapy.