TABLE I.

Concurrent paclitaxel and radiotherapy in breast cancer

Reference	Pts (n)	Paclitaxel		Radiotherapy dosing (cGy)	Toxicity
		Dose (mg/m2)	Schedule
Elmongy et al., 199943	32	175–225	Every 3 weeks	5040–6300	Grade 3 skin toxicity: 9
Bellon et al., 200044	8	20–35×4 days	Every 3 weeks	4680–5040	Acute skin toxicity requiring
	9	135–175	Every 3 weeks	plus boost	delay exceeding 5 days: 6
Taghian et al., 200145	7	175	Every 3 weeks	4000–4600	Pneumonitis: 3 of the 21
	14	60–100		plus 600–2000 boost
Hanna et al., 200246	20	175	Every 3 weeks ×3	bcs: 4500 plus 1600 mast: 5040 plus 1000	Grade 3 skin toxicity: 7 Pneumonitis: 4
Formenti et al., 200347	44	30	Twice weekly	4500 plus 1800	Grade 3 skin toxicity: 3
Kao et al., 200548	16	20–30×4 days	Every 2 weeks	6000	Greater than grade 3 skin toxicity:
	17	80	Weekly		8 of the 33
Burstein et al., 200649	16	60	Weekly	mast: 4500 plus 400–1000	Pneumonitis in 3 of 16
	24	135–175	Every 3 weeks	bct: 4500 plus 1000–1600
Chakravarthy et al., 200650	38	30	Twice weekly	4500 plus 1400	Skin toxicity: 1
Chen et al., 201051	44	175	Every 3 weeks	3960 plus 1400	Grade 3 skin toxicity: 2

Pts = patients; bcs = breast-conserving surgery; mast = mastectomy; bct = breast-conserving therapy.