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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Exp Neurol. 2014 Nov 26;264:1–7. doi: 10.1016/j.expneurol.2014.11.007

Figure 2.

Figure 2

Post-stroke treatment with ICV administration of miR-181a antagomir 2 hours after MCAO protects brain. A. ICV injection of antagomir results in significantly reduced levels of miR-181a 24 hours later, N=5 mice/group. B. Infarct volume assessed at 48 hours reperfusion was reduced and C. the neurologic deficit score at 24 hours was improved, N=9. * indicates p<0.05 compared to MM control. D. ICV injection of antagomir results in better recovery of rotarod performance after MCAO. Sham treated mice in miR-181a antagomir group (n = 6) and MM group (n = 6) and MCAO mice in miR-181a antagomoir group (n = 21) and MM group (n = 22) learned the task and by the 9 times training performance exceeded 270 seconds. * p<0.05 vs sham control; # p<0.05 vs MM control. MM: mismatched control, con: control; antag: antagomir.