. Author manuscript; available in PMC: 2015 Nov 13.

Published in final edited form as: Arch Med Res. 2014 Nov 13;45(8):744–752. doi: 10.1016/j.arcmed.2014.11.003

Table 2.

Top scored maps of the pathway gene enrichment analysis of the HIV + Aβ + Dy vs. HIV + Aβ treatment groups

Maps with genes
Apoptosis and survival–endoplasmic reticulum stress response pathway: ATF-4, I-κB, DNAJC3, XBP1, GRP78, C/EBP zeta, Derlin-2, c-Jun, HERP, ERP5 Influence of low doses of arsenite on glucose stimulated insulin secretion in pancreatic cells: ATF-4, oxidized thioredoxin, thioredoxin, heme oxygenase 1, NQO1, SRX1, GCL reg Immune response–IL-1 signaling pathway: IL-6, heme oxygenase 1, I-kB, AP-1, c-Jun/c-Jun, PAI1, c-Jun Cell cycle–initiation of mitosis: Cyclin B1, PLK1, FOXM1, CDK1 (p34), CDK7 DNA damage–ATM/ATR regulation of G2/M checkpoint: GADD45 alpha, Cyclin A, Cyclin B, CDK1 (p34), GADD45 B Oxidative stress–role of sirtuin1 and PGC1-alpha in activation of antioxidant defense system: oxidized thioredoxin, sequestosome 1(p62), thioredoxin, heme oxygenase 1, NQO1, GCL reg, SLC7A11 Immune response–MIF–the neuroendocrine-macrophage connector: casein kinase II, alpha chains, oxidized thioredoxin, PLA2, thioredoxin, PKA-reg (cAMP-dependent), IP3 receptor Cytoskeleton remodeling - TGF, WNT and cytoskeletal remodeling: Casein kinase II, alpha chains, LRP5, SMAD2, Fibronectin, MSK1, PAI1, PLAU (UPA), Frizzled, c-Jun Cell cycle - Role of APC in cell cycle regulation: CDC18 L (CDC6), Cyclin A, PLK1, Cyclin B, CDK1 (p34) Development - TGFβ receptor signaling: SMAD2, FKBP12, MSK1, PAI1, NFKBIA, GADD45B

Maps with genes

Apoptosis and survival–endoplasmic reticulum stress response pathway: ATF-4, I-κB, DNAJC3, XBP1, GRP78, C/EBP zeta, Derlin-2, c-Jun, HERP, ERP5
Influence of low doses of arsenite on glucose stimulated insulin secretion in pancreatic cells: ATF-4, oxidized thioredoxin, thioredoxin, heme oxygenase 1, NQO1, SRX1, GCL reg
Immune response–IL-1 signaling pathway: IL-6, heme oxygenase 1, I-kB, AP-1, c-Jun/c-Jun, PAI1, c-Jun
Cell cycle–initiation of mitosis: Cyclin B1, PLK1, FOXM1, CDK1 (p34), CDK7
DNA damage–ATM/ATR regulation of G2/M checkpoint: GADD45 alpha, Cyclin A, Cyclin B, CDK1 (p34), GADD45 B
Oxidative stress–role of sirtuin1 and PGC1-alpha in activation of antioxidant defense system: oxidized thioredoxin, sequestosome 1(p62), thioredoxin, heme oxygenase 1, NQO1, GCL reg, SLC7A11
Immune response–MIF–the neuroendocrine-macrophage connector: casein kinase II, alpha chains, oxidized thioredoxin, PLA2, thioredoxin, PKA-reg (cAMP-dependent), IP3 receptor
Cytoskeleton remodeling - TGF, WNT and cytoskeletal remodeling: Casein kinase II, alpha chains, LRP5, SMAD2, Fibronectin, MSK1, PAI1, PLAU (UPA), Frizzled, c-Jun
Cell cycle - Role of APC in cell cycle regulation: CDC18 L (CDC6), Cyclin A, PLK1, Cyclin B, CDK1 (p34)
Development - TGFβ receptor signaling: SMAD2, FKBP12, MSK1, PAI1, NFKBIA, GADD45B