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Orbital meningioma subtypes have different cytogenetic abnormalities. Chromosome 22 loss was frequent in ectopic orbital meningiomas (A) but rare in meningiomas of the optic nerve proper which usually had no alterations in Ch 22 (B). Conversely, optic nerve meningiomas contained other less frequent abnormalities. In this example alterations in chromosome 2 (del 2pter‐p16.3, del 2q22.1‐qter) are shown (C).
