Table 1.
Baseline demographic and clinical characteristics
| Characteristic | Total
|
Neoadjuvant patients
|
Surgery-only patients
|
P |
|---|---|---|---|---|
| n = 1939 | n = 708 (36.5%) | n = 1231 (63.5%) | ||
| Age, mean (median) | 63.9 ± 10.5 (65) | 62.3 ± 10.2 (63) | 64.7 ± 10.5 (65) | <0.001 |
| Male (%) | 1618 (83.6) | 601 (84.9) | 1017 (82.8) | 0.237 |
| Race (%) | 0.382 | |||
| White | 1634 (84.3) | 610 (86.2) | 1024 (83.2) | |
| Black | 57 (2.9) | 19 (2.7) | 38 (3.1) | |
| Other | 61 (3.2) | 19 (2.7) | 42 (3.4) | |
| Unknown | 187 (9.6) | 60 (8.5) | 127 (10.3) | |
| ASA classification (%) | 0.446 | |||
| No disturb/mild disturb | 414 (21.4) | 142 (20.1) | 272 (22.1) | |
| Serious disturb | 1386 (71.5) | 511 (72.2) | 875 (71.1) | |
| Life threat/moribund | 138 (7.1) | 55 (7.8) | 83 (6.8) | |
| Body mass index | 27.7 ± 6.1 | 26.8 ± 5.8 | 28.2 ± 6.2 | <0.001 |
| Diabetes (%) | 360 (18.6) | 113 (16.0) | 247 (20.1) | 0.025 |
| Current smoker (%) | 502 (25.9) | 206 (29.1) | 296 (24.1) | 0.015 |
| Alcohol consumption (%) | 93 (4.8) | 29 (4.1) | 64 (5.2) | 0.274 |
| Dyspnea (%) | 211 (10.9) | 76 (10.7) | 135 (11.0) | 0.874 |
| History of COPD (%) | 143 (7.4) | 51 (7.2) | 92 (7.5) | 0.827 |
| History of CHF (%) | 2 (0.1) | 2 (0.3) | 0 (0.0) | 0.133 |
| History of MI (%) | 13 (0.7) | 6 (0.9) | 7 (0.6) | 0.469 |
| Hypertension (%) | 1051 (54.2) | 335 (47.3) | 716 (58.2) | <0.001 |
| Previous cardiac surgery (%) | 133 (6.9) | 35 (4.9) | 98 (8.0) | 0.011 |
| Weight loss (%) | 404 (20.8) | 208 (29.4) | 196 (15.9) | <0.001 |
| Steroid use (%) | 29 (1.5) | 9 (1.3) | 20 (1.6) | 0.537 |
| Year of operation (%) | 0.003 | |||
| 2005–2007 | 473 (24.4) | 147 (20.8) | 326 (26.5) | |
| 2008–2009 | 720 (37.1) | 258 (36.4) | 462 (37.5) | |
| 2010–2011 | 746 (38.5) | 303 (42.80) | 443 (36.0) | |
| Preoperative WBC (%) | <0.001 | |||
| Normal (4.5–11 × 109/L) | 1507 (79.8) | 490 (70.7) | 1017 (85.0) | |
| Abnormal (<4.5 or >11 × 109/L) | 382 (20.2) | 203 (29.3) | 179 (15.0) | |
| Preoperative hematocrit (%) | <0.001 | |||
| Normal (≥36) | 1178 (62.8) | 347 (50.3) | 831 (70.0) | |
| Abnormal (<36) | 699 (37.2) | 343 (49.7) | 356 (30.0) |
Different denominators due to missing data: gender (n = 1936; n1 = 708; n2 = 1228); WBC (n = 1889; n1 = 693; n2 = 1196); Hematocrit (n = 1877; n1 = 690; n2 = 1187). Bold indicates statistically significant values. ASA, American Society of Anesthesiology; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; MI, myocardial infarction; WBC, white blood cell.