Table 3.

Classifying HNSCC progression-free survival (PFS) and overall survival (OS) for different HNSCC patient subgroups using the rules devised in Poeta et al. with and without splice-site consideration

Surgical group	Survival	Classifier	HR (D vs. ND)	HR, 95 % CI	P value
All patients with mutated TP53 (n = 224)	PFS	Poeta rules + Splice	1.50	1.10–2.04	0.01
		Poeta rules	1.43	1.04–1.95	0.03
	OS	Poeta rules + Splice	1.34	0.96–1.89	0.09
		Poeta rules	1.40	1.00–1.98	0.05
Recurrent only (n = 39)	PFS	Poeta rules + Splice	2.12	1.07–4.22	0.03
		Poeta rules	2.08	1.04–4.16	0.04
	OS	Poeta rules + Splice	1.93	0.92–4.03	0.08
		Poeta rules	2.50	1.19–5.23	0.02
Surgery only (n = 69)	PFS	Poeta rules + Splice	1.98	1.10–3.57	0.02
		Poeta rules	1.72	0.93–3.17	0.08
	OS	Poeta rules + Splice	1.30	0.68–2.48	0.42
		Poeta rules	1.03	0.51–2.08	0.94
Surgery + postoperative therapy (n = 114)	PFS	Poeta rules + Splice	1.21	0.78–1.87	0.40
		Poeta rules	1.18	0.76–1.82	0.47
	OS	Poeta rules + Splice	1.28	0.79–2.09	0.31
		Poeta rules	1.42	0.88–2.30	0.16
Surgery only combined with surgery + postoperative therapy (n = 183)	PFS	Poeta rules + Splice	1.45	1.02–2.06	0.04
		Poeta rules	1.33	0.93–1.90	0.11
	OS	Poeta rules + Splice	1.28	0.87–1.89	0.21
		Poeta rules	1.26	0.85–1.86	0.25

HR is the hazard ratio calculated for disruptive (D) vs. non-disruptive (ND) classifications, CI is the confidence interval, and n is the number of patients in the corresponding subgroup

Results for All patients with mutated TP53 are shown for comparison, and are the same as in Tables 1 or 2