Table 4.

Correlation of predictions made by each classifier and the WAF1 ≤20 % classifier

Classifier	FDR-adjusted P value
Poeta rules	2.03 × 10−3
Density ≥0.5	1.31 × 10−10
Distance ≤20 Å	3.58 × 10−11
Distance ≤10 Å	1.99 × 10−8
PPH-2 possibly	3.58 × 10−11
PPH-2 probably	3.58 × 10−11
VEST ≥0.4	4.37 × 10−11
VEST ≥0.8	3.77 × 10−11
AGVGD C45	1.20 × 10−8
AGVGD C35	5.22 × 10−10
SIFT	3.58 × 10−11
POSE	1.48 × 10−10

The Poeta + splice and WAF1 ≤ 20 % predictions were not significantly co-occurring. The WAF1 ≤ 10 % classifier was not included in the calculation to prevent an artificially conservative FDR adjustment

Two-tailed Fisher’s exact P values were calculated by populating a two-by-two contingency table with predictions made by each classifier and those made by the WAF1 ≤20 % classifier (disruptive = 1; non-disruptive = 0); P values were adjusted using the Benjamini and Hochberg false-discovery rate (FDR)