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. Author manuscript; available in PMC: 2016 Jun 4.
Published in final edited form as: Oncogene. 2014 Aug 11;34(23):2958–2967. doi: 10.1038/onc.2014.245

Figure 1. GD3S plays an important role in the initiation and maintenance of EMT.

Figure 1

(a-c) GD3S was inhibited in the studied cell lines either by shRNA-mediated silencing (a) or by treating the cells with triptolide (c) and the phenotype was examined along with western analysis for epithelial and mesenchymal markers (b). Morphological analysis (d) as well as western analysis (e) of TGF-β1 treated MCF-10A cells in the presence or absence of GD3S. (f-i) Morphology (f, h) and western analysis (g, i) of tamoxifen-treated HMLE-Snail-ER cells after inhibition of GD3S by either shRNA (f, g) or triptolide (h, i).