Figure 3.

Cellular energy and metabolism pathways involving HERC2. GePS analysis of HERC2 HCIPs yielded 14 distinct GO biological process terms regarding processes involved in energy and cellular metabolism (Table 3). Nineteen HERC2-interacting genes were represented, 10 of which were not linked in any network. Four of the unlinked genes (ENPP1, ITPR2, ARNT, SCO2) and all other linked genes were extended by known interactions to other input genes and reorganized to generate the major network shown in B. Network HCIPs and the corresponding HERC2 fragment used for identification are displayed in A (five HCIPs were identified with more than one fragment). Nodes are colored according to the gene’s NWD score from the HERC2 CompPASS analysis.