Figure 1.

Chemical structures of SalAA foldamers explored in this study. (A) Schematic (left) and crystal structure (right) of a dimeric foldamer based on the salicylamide backbone, Ac-Sal-Gly-Sal-NMe amide, in which Ac is acetyl, Sal is the indicated amino-salicylic acid methyl ether unit, Gly is glycine, and NMe amide is an N-methyl amide. (B) Chemical structures of salicylamide-α-amino acid peptides (SalAA foldamers) for C-terminal and N-terminal (C) modified series. (D) Chemical structure of compound 7, (d-Cit-Sal)₄-CONH₂; in this variant of (Lys-Sal)₄-CONH₂, compound 1, cationic lysine is replaced with a neutral citrulline amino acid.