Table 4.
Predictors of treatment success and death in patients with MDR-TB from the community-based sites and centralised hospital in KwaZulu-Natal, South Africa
| Predictors of treatment success | ||||
|---|---|---|---|---|
| Variables | Unadjusted Odds Ratio (95% CI) |
p-value | Multivariate Odds Ratio (95% CI) |
p-value |
| Community-based site | 1.19 (0.91 to 1.57) | 0.207 | 1.43 (1.09 to 1.88) | 0.010 |
| Female gender | 1.21 (1.09 to 1.36) | <0.001 | 1.19 (1.05 to 1.34) | 0.007 |
| Age≥30 years | 1.28 (1.01 1.63) | 0.042 | 1.40 (1.18 to 1.65) | <0.001 |
| No previous MDR-TB | 2.63 (2.05 to 3.39) | <0.001 | 2.51 (1.64 to 3.84) | <0.001 |
| HIV and ART status | ||||
| HIV positive, on ART HIV negative HIV positive, not on ART |
1.63 (1.40 to 1.89) 1.43 (1.08 to 1.90) Reference |
<0.001 0.012 | 1.5 (1.38 to 1.62) 1.35 (1.05 to 1.75) Reference |
<0.001 0.021 |
| Weight, ≥50 kg female or ≥55 kg male | 1.31 (1.06 to 1.63) | 0.013 | 1.28 (1.06 to 1.56) | 0.011 |
| Length of hospitalization^ | 1.01 (0.99 to 1.01) | 0.091 | ** | |
| Culture conversion <90 days from Rx start¶ |
1.71 (1.44 to 2.03) | <0.001 | ** | |
|
| ||||
| Predictors of death | ||||
|
| ||||
| Variables |
Unadjusted
Hazards Ratio (95%) CI) |
p-value |
Multivariate Hazards
Ratio (95% CI) |
p-value |
| Community-based Site | 1.27 (0.82 to 1.96) | 0.289 | 1.06 (0.87 to1.30) | 0.567 |
| Age, ≥30 years | 1.70 (1.03 to 2.83) | 0.039 | 1.61 (1.09 to 2.38) | 0.018 |
| Low pre-treatment weight, ≤50 kg female or≤55 kg male |
1.35 (0.88 to 2.05) | 0.161 | 1.40 (1.00 to 1.96) | 0.048 |
| Previous TB or MDR-TB | 0.82 (0.58 to 1.19) | 0.312 | 1.28 (0.78 to 2.09) | 0.324 |
| Year treatment started | ||||
| 2008 2009 2010 |
1.78 (1.35 to 2.35) 1.27 (1.09 to 1.48) Reference |
<.001 .002 | 1.77 (1.36 to 2.31) 1.53 (1.05 to 2.22) Reference |
<0.001 0.027 |
| HIV and ART status | ||||
| HIV positive, not on ART HIV positive, on ART HIV negative |
2.12 (1.54 to 2.93) 1.23 (0.93 to 1.63) Reference |
<0.001 0.154 |
1.59 (0.98 to 2.59) 1.01 (0.72 to 1.41) Reference |
0.062 1.006 |
| Median baseline CD4 count (cells per μL) |
** | |||
| <50 50-199 200+ |
1.90 (1.11 to 3.26) 1.02 (0.80 to 1.31) Reference |
0.019 0.853 |
||
| Length of hospitalization^ | 0.92 (0.88 to 0.96) | <0.001 | ** | |
| Extensive chest disease‡ | 2.54 (1.00 to 6.44) | 0.049 | ** | |
HIV = human immunodeficiency virus
ART = antiretroviral therapy
^
For every additional 14 day stay
¶
culture conversion <90 days defined as two consecutive negative sputum cultures taken at least 1 month apart less than 90 days after treatment started.
**
Not included in multivariate model because too few non-missing values.
‡
Extensive chest disease defined if bilateral involvement or cavities present on chest X-ray.