. Author manuscript; available in PMC: 2015 May 1.

Published in final edited form as: Int J Tuberc Lung Dis. 2015 Feb;19(2):163–171. doi: 10.5588/ijtld.14.0369

Table 5.

Treatment outcomes stratified by HIV status in patients with MDR-TB in KwaZulu-Natal, South Africa^¶

	HIV positive			HIV negative
	Centralised Hospital	All community- based sites	p-value	Centralised Hospital	All community- based sites	p-value
	n=576	n=528		n=212	n=164
Cured^*	200 (34.7)	286 (54.2)	<0.001	71 (33.5)	79 (48.2)	<0.001
Treatment completed^¥	109 (18.9)	35 (6.6)	<0.001	46 (21.7)	16 (9.8)	<0.001
Treatment success^**	309 (53.6)	321 (60.8)	0.013	117 (55.2)	95 (57.9)	0.372
Died^†	82 (14.2)	98 (18.6)	0.114	24 (11.3)	19 (11.6)	0.970
Failed^{^}	23 (4.0)	32 (6.1)	<0.001	5 (2.4)	14 (8.5)	0.008
Default^‡‡	160 (27.8)	65 (12.3)	<0.001	66 (31.1)	32 (19.5)	0.025
Transferred out^{^^}	2 (0.4)	12 (2.3)	^**	0	4 (2.4)	^**

Data are number (%), unless otherwise indicated

^¶

Treatment outcome definitions used are WHO definitions for the management of MDR-TB (Box 1). ^17,18

Cured: Cure was defined as completion of treatment and >5 consecutive negative culture results in the final 12 months of treatment. A patient was still considered cured If only one positive culture was reported during this time, was clinically well, and this positive culture was followed by at least 3 consecutive negative cultures taken at least 30 days apart.

^¥

Treatment completed: Treatment completion referred to completion of therapy but without bacteriologic documentation of cure.

^**

Treatment success: Treatment success has been defined as the percentage of patients in whom the treatment outcome was either cured or completed. That is, “% successful = no. of patients cured + no. of patients completed treatment /Total no. initiated treatment × 100”.has been defined as the percentage of patients in whom the treatment outcome was either cured or completed. That is, “% successful = no. of patients cured + no. of patients completed Rx/Total no. initiated Rx × 100.

^†

Died: Death was defined as all-cause mortality during MDR-TB treatment.

^{^}

Failed: Treatment failure was defined as having more than one positive culture in the final 12 months of therapy, or if any one of the final three cultures was positive, or if more than one drug in the treatment regimen was replaced, or if treatment was terminated due to adverse events or no clinical improvement.

^‡‡

Default: Default was defined as an interruption in treatment for > 2 consecutive months for any reason.

^{^^}

Transferred out: A patient with MDR-TB who was transferred to another reporting and recording unit a year after study-enrolment whose treatment outcome is unknown.