Table 1.
16 pathway-based biomarkers identified.
| PATHWAY ID | PATHWAY NAME | AE | N | ES | FDR |
|---|---|---|---|---|---|
| h_classicPathway | Classical complement pathway | 14 | 14 | 0.70549 | 0.07245 |
| 500792 | GPCR ligand binding | 16 | 409 | 0.60928 | 0.08991 |
| hsa05322 | Systemic lupus erythematosus | 17 | 141 | 0.68254 | 0.10214 |
| 166663 | Initial triggering of complement | 13 | 63 | 0.64665 | 0.10883 |
| h_lectinPathway | Lectin-induced complement pathway | 10 | 12 | 0.76798 | 0.1105 |
| h_compPathway | Complement pathway | 16 | 19 | 0.66422 | 0.12402 |
| 200149 | PDGFR-beta signaling pathway | 12 | 129 | 0.70522 | 0.16918 |
| hsa04610 | Complement and coagulation cascades | 42 | 71 | 0.50477 | 0.17074 |
| 373076 | Class A/1 (Rhodopsin-like receptors) | 10 | 304 | 0.7634 | 0.1732 |
| 375276 | Peptide ligand–binding receptors | 10 | 185 | 0.7634 | 0.1732 |
| 392499 | Metabolism of proteins | 18 | 378 | 0.56802 | 0.21487 |
| 381150 | Diabetes pathways | 15 | 137 | 0.57968 | 0.21726 |
| 388396 | GPCR downstream signaling | 27 | 866 | 0.48634 | 0.22031 |
| hsa05133 | Pertussis | 18 | 84 | 0.5792 | 0.22171 |
| hsa05150 | Staphylococcus aureus infection | 16 | 69 | 0.58669 | 0.22746 |
| 418594 | G alpha (i) signaling events | 12 | 199 | 0.67202 | 0.23845 |
Notes: AE is the number of genes presented in the pathway. N is the total number of genes in the pathway.