Table 2.
Organ/tissue concentration and biodistribution of 68Ga-DOTA-TBIA101 in Escherichia coli infected mice.
| Organ/tissue |
Activity concentration (SUV) |
Compound distribution (%ID) |
||
|---|---|---|---|---|
| Infected | Healthy control* | Infected | Healthy control | |
| Heart | 16 ± 2.2 | 0.43 | 9.5 | 8.9 |
| Lung | 0.73 ± 0.03 | 0.48 | 0.50 | 0.50 |
| Liver | 25 ± 3.9 | 14 | 14 | 14 |
| Kidneys | 59 ± 6.3 | 35 | 36 | 36 |
| Brain | 0.90 ± 0.1 | 0.55 | 0.55 | 0.57 |
| Intestine | 0.90 ± 0.1 | 0.54 | 0.58 | 0.57 |
| Urinary tract/bladder | 34 ± 2.9 | 20 | 21 | 21 |
| Forearm muscle | 1.1 ± 0.2 | 0.58 | 0.63 | 0.60 |
| Hind muscle (CL) | 1.5 ± 0.3 | 0.73 | 0.77 | 0.76 |
| Hind muscle (E.coli) | 1.7 ± 0.3 | 0.73 | 0.94 | 0.76 |
| Hind muscle (CL) to forearm muscle | 1.4 ± 0.1 | NA | NA | NA |
| Hind muscle (E.coli) to background ratio | 2.3 ± 0.5 | NA | NA | NA |
| Hind muscle (E.coli) to forearm muscle | 1.6 ± 0.1 | NA | NA | NA |
| Hind muscle (E.coli) hind muscle (CL) | 1.2 ± 0.1 | NA | NA | NA |
Values expressed as mean ± SEM. E.coli = Escherichia coli 22952 (n = 3), healthy control (n = 1), and CL = contralateral. *The SUV values were calculated from the same region of interest area using one healthy animal.