TABLE 2.

Incidence of mutation and association with OS for individual and combinations of mutations

Characteristic	n (%)	HR	95 % CI	P	Median OS, mo
WT	92 (56.8)	Ref		–	31.35
Any mutations	70 (43.2)	1.10	0.72–1.68	0.66	31.38
BRAF	8 (4.9)	1.06	0.38–2.94	0.92	25.46
CTNNB1	1 (0.6)	1.17	0.16–8.55	0.88	–
KRAS	14 (8.6)	1.99	0.96–4.12	0.07	20.33
MAP2K1	3 (1.9)	1.74	0.54–5.64	0.36	26.94
NRAS	5 (3.1)	1.01	0.25–4.19	0.98	28.62
PIK3CA	7 (4.3)	0.55	0.17–1.76	0.31	37.34
PTEN	1 (0.6)	1.11	0.15–8.09	0.92	–
TP53	4 (2.5)	1.26	0.39–4.08	0.70	10.82
KRAS or NRAS	19 (11.7)	1.69	0.86–3.30	0.13	28.62
KRAS or NRAS or BRAF	27 (16.7)	1.44	0.80–2.59	0.22	25.46
MAP2K1 + PIK3CA	1 (0.6)	1.23	0.17–8.99	0.84	–
KRAS or BRAF	22 (13.6)	1.54	0.83–2.87	0.17	20.33
PIK3CA or PTEN	8 (4.9)	0.62	0.22–1.73	0.36	43.26

Full mutational profiling except for IDH (n = 162)

OS overall survival, HR hazard ratio, CI confidence interval, WT wild type