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Ribbon diagrams of ALK with covalently bound BNP7787-derived mesna adducts (PDB IB code 4TT7).
Notes: (A) BNP7787-derived mesna adducts observed at Cys 1235 and Cys 1156. (B) Overlay of region of apo-ALK (pink) with BNP7787-xenobiotically modified ALK (lavender) that has a Cys 1156-mesna adduct. The BNP7787-derived mesna adduct occupies the same pocket as Phe 1127 of the P-loop.
Abbreviation: ALK, anaplastic lymphoma kinase.
