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. 2015 Feb 4;8:375–383. doi: 10.2147/OTT.S73690

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© 2015 Parker et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Electron density and binding site maps showing BNP7787-derived mesna-cysteine adducts on ALK.

Notes: 2Fo-Fc electron density map contoured at 1 sigma showing BNP7787-derived mesna-cysteine adducts on ALK at (A) Cys 1235 and (B) Cys 1156. (C) Binding site of the BNP7787-derived mesna-cysteine adduct at Cys 1235. There are no obvious interactions of the BNP7787-derived mesna with the protein other than the covalent bond with Cys 1235. (D) Molecular surface of ALK with the BNP7787-derived mesna at Cys 1156 removed to show the interaction of the adduct with the protein. A water-mediated hydrogen bond is present between the BNP7787-derived mesna sulfonate and Asp 1160 carbonyl.

Abbreviation: ALK, anaplastic lymphoma kinase.