Fig. 2. S492 is a critical node in ΔF508-NBD1. (a) Number of nodes in the largest component (y-axis) of the disconnected sub-graph after disconnecting the corresponding residue (x-axis). We consider residues that partition the sub-graph into connected components of ten or more residues as critical nodes. Different colors represent different components. (b) Network representation of the disconnected sub-graph. S492 forms a critical node that partitions the sub-graph into two connected components of nearly equal size (yellow and gray circles). Yellow nodes with black outline represent residues in the RI. Smaller components are represented as white circles.