Fig. 3.

Sprayed application of optimized orotopical delivery vehicle to assess surface coating and retention properties. Oral cavity (a) before, (b) following 1× 0.10 ml sprayed application from a Madomizer applicator and (c) following 15×0.10 ml sprayed applications. (c) Excess topical vehicle from the 15 sprays can be seen pooled (arrows) in the buccal-gingival trough. In a parallel experiment, dental cotton rolls were placed in the buccal-gingival trough just before either 10 or 15×0.10 ml sprayed applications to the buccal wall. Cotton rolls were then retrieved (C inset) to assess amount of excess topical formulation that had not been retained on the buccal wall.