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Fyn kinase structure and regulation. Fyn kinase consists of SH1-4 domains. The SH2 domain binds the phosphorylated Y528 in the C-terminus, locking Fyn in an inactive conformation. Y528 is dephosphorylated by phosphatases (PTPs), opening the structure and allowing Y416 in the catalytic SH1 domain to be phosphorylated.
