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. Author manuscript; available in PMC: 2015 Feb 11.
Published in final edited form as: Nat Genet. 2014 Sep 7;46(10):1060–1062. doi: 10.1038/ng.3091

Figure 1.

Figure 1

Recurrent mutations in KNSTRN encoding p.Ser24Phe in cutaneous SCC. (a) The percentages of somatic point mutations in 100 primary cutaneous SCCs that are transitions compared to transversions. (b) Characterization of SCC–matched normal pairs. Mutation frequency is shown in parentheses next to each gene name. FFPE, formalin fixed and paraffin embedded. (c) Distribution of the SCC-associated alterations identified in this study across the kinastrin coding sequence. SXLP, SXLP motif; CC, coiled-coil region. (d) Detection of KNSTRN mutation encoding p.Ser24Phe in SCC precursor actinic keratoses (AKs) as well as primary SCCs by allelic discrimination quantitative PCR. NL, freshly excised normal skin. Data shown represent technical triplicates. WT, wild type.