Table 3.
Neuropsychological test performance of HIV seronegative and HIV seropositive (entire and matched) participants
| HIV− controls (n=20)
|
All HIV+ (n=49)
|
Effect size (all HIV+ vs. HIV−) | Matched HIV+ (n=31)
|
Effect size (matched) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | ||||
| Verbal fluency | Letter fluency | 35.8 | 10.2 | 27.4 | 10.2 | −0.81** | 30.1 | 10.4 | −0.54 |
| Animal fluency | 18.6 | 4.7 | 17.5 | 5.0 | −0.22 | 18.5 | 5.1 | −0.02 | |
| Action fluency | 14.2 | 5.8 | 10.6 | 4.9 | −0.69* | 11.8 | 5.1 | −0.44 | |
| Speed of information processing | Digit symbol | 69.6 | 12.5 | 58.4 | 16.3 | −0.72** | 63.8 | 15.3 | −0.40 |
| Symbol search | 31.9 | 6.6 | 24.7 | 8.7 | −0.87** | 28.1 | 8.0 | −0.50 | |
| Trails A | 37.0 | 9.6 | 48.1 | 19.9 | 0.62* | 42.2 | 17.1 | 0.35 | |
| Color trails 1 | 44.4 | 18.6 | 54.4 | 26.4 | 0.40 | 48.1 | 21.7 | 0.10 | |
| Stroop word (#) | 95.8 | 13.5 | 85.8 | 15.2 | −0.67* | 89.4 | 14.9 | −0.44 | |
| Stroop color (#) | 72.4 | 10.2 | 63.7 | 12.1 | −0.74** | 67.2 | 11.9 | −0.45 | |
| Attention/working memory | PASAT-50 | 35.7 | 9.0 | 26 | 11 | −0.92** | 29.3 | 11.6 | −0.59* |
| Spatial span | 17.3 | 2.3 | 15.6 | 4.5 | −0.42 | 17.0 | 4.0 | −0.09 | |
| Executive functioning | Category test | 38.9 | 16.9 | 56.9 | 26.4 | 0.74** | 49.5 | 26.8 | 0.44 |
| WCST-64 | 8.5 | 4.0 | 12.8 | 6.2 | 0.75** | 11.3 | 5.3 | 0.57* | |
| Stroop incong (#) | 43.6 | 12.9 | 36.7 | 10.0 | −0.63* | 39.3 | 8.9 | −0.40 | |
| Color trails 2 | 78 | 21.5 | 97.9 | 47.2 | 0.47 | 87.1 | 48.8 | 0.22 | |
| Learning | BVMT-R learning | 27.5 | 5.2 | 23.4 | 6.1 | −0.69* | 25.5 | 5.7 | −0.36 |
| HVLT-R learning | 27.9 | 3.6 | 26 | 4.5 | −0.44 | 27.1 | 4.5 | 0.19 | |
| Recall | BVMT-R delay | 9.9 | 1.4 | 8.9 | 2.4 | −0.46 | 9.7 | 2.1 | −0.11 |
| HVLT-R delay | 9.8 | 1.6 | 9.0 | 2.1 | −0.40 | 9.3 | 2.0 | −0.27 | |
| Motor | Pegs dominant | 62.7 | 8.6 | 77.4 | 14.2 | 1.13*** | 75.4 | 13.1 | 1.08*** |
| Pegs non-dom | 71.6 | 9.9 | 83.1 | 18.4 | 0.69* | 80.2 | 18.6 | 0.54 | |
| Global | % impaired | 10 % | 59 % | 38.7 % | |||||
p<0.05;
p<0.01;
p<0.001
PASAT paced auditory serial addition task, WCST Wisconsin card sorting test, HVLT-R Hopkins verbal learning test-revised, BVMT-R brief visuospatial memory test-revised