Table 1.
Characteristics and factors known to influence engraftment in 24 consecutive HLA haploidentical stem cell recipients receiving their first transplant.
| Engrafted | Graft failure | p- value |
|
|---|---|---|---|
| Number | 20 | 4 | |
| Median age (yrs) | 33.5 | 38 | 0.85 |
| Diagnosis | 1.0 | ||
| AML/MDS | 16 | 4 | |
| ALL | 2 | 0 | |
| CML | 1 | 0 | |
| Lymphoma | 1 | 0 | |
| Disease status at transplant | |||
| Not in remission | 12 | 3 | 0.59 |
| Alloreactive KIR-ligand mismatch in HVG direction | 0.62 | ||
| 0 | 14 | 4 | |
| 1 | 5 | 0 | |
| 2 | 1 | 0 | |
| Sex mismatch | 0.89 | ||
| Male recipient/female donor | 4 | 0 | |
| Female recipient/male donor | 6 | 2 | |
| Female recipient/female donor | 4 | 1 | |
| Male recipient/male donor | 6 | 1 | |
| CMV mismatch | 1.0 | ||
| Recipient+/Donor+ | 11 | 2 | |
| Recipient+/Donor− | 8 | 2 | |
| Recipient−/Donor+ | 1 | 0 | |
| Recipient−/Donor− | − | − | |
| Median # HLA mismatches | |||
| High expression loci (A, B, C, DRB1) | 4 | 4 | 0.63 |
| Low expression loci (DBR3, 4, 5, DQB1) | 1 | 1 | 0.47 |
| ABO mismatch | 0.27 | ||
| Compatible | 9 | 0 | |
| Minor | 5 | 2 | |
| Major | 4 | 1 | |
| Minor and major | 2 | 1 | |
| Median # CD34+ cells infused (×106/kg) (range) | 8.7 (6–20.8) | 12.8 (6.72–17.5) | 0.22 |
AML – acute myeloid leukemia; ALL – acute lymphoblastic leukemia; CML – chronic myeloid leukemia; KIR – killer immunoglobulin-like receptors; HVG – host-versus-graft; CMV – cytomegalovirus; ABO – Blood group mismatches; major mismatch occurs when donor’s RBC-ABO blood group is incompatible with the recipient’s plasma, minor mismatch occurs when recipients RBC-ABO blood group is incompatible with the donor’s plasma.