Table 2.
Characteristics of five patients who received a haploidentical stem cell transplant at UTMDACC and had donor-specific anti-HLA antibodies.
| Patient # | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|
| Age | 43 | 37 | 26 | 39 | 50 |
| Gender | F | F | F | F | F |
| Diagnosis | AML | AML | AML | AML | AML |
| % BM blasts at transplant | 0 | 13 | 1 | 23 | 4 |
| Donor | Sib | Sib | Sib | Son | Daughter |
| # HLA mismatches* | 3 | 4 | 2 | 5 | 2 |
| Cell type | PB | PB | PB | PB | PB |
| # CD34+ cells infused (×10e6/kg) | 14.8 | 6.6 | 17.5 | 17.5 | 9.4 |
| # Pregnancies | 0 | 3 | 3 | 2 | 3 |
| # PRBCs transfused prior to transplant | 37 | 41 | 17 | 65 | 32 |
F- female; AML – acute myeloid leukemia; BM – bone marrow; Sib – sibling; PB – peripheral blood; PRBCs – packed red blood cells;
Number of allele mismatches in HLA A, B, C, DRB1, DQB1 loci