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. 2015 Feb 3;14:15. doi: 10.1186/s12933-015-0182-7

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© Schuette et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Clinical study design. Legend: Schematic representation of the study design. Patients presenting stable coronary heart disease with or without type-2 diabetes were enrolled. A 300 mg loading dose of clopidogrel was given to clopidogrel-naïve patients. All other patients were given a daily maintenance dose of 75 mg clopidogrel. In addition, all patients received acetylsalicylic acid (ASA; 100 mg/day). Blood samples were drawn 24 h after coronary angiography with percutaneous coronary intervention (PCI), and agonist-induced platelet aggregation measurements were performed.