Figure 2.

Snapshot of Amiodarone at the binding belt, as a characteristic example of three crucial protein – drug interactions. Residues are color coded according to the type of interaction exhibited with Amiodarone. Residues V978, I977, and L971 are colored red and represent hydrophobic packing interactions characterized by weak electrostatic forces. Residues M74 and M67 are colored green. The dashed lines represent the hydrogen bonding between the sulfur atoms of M74, M67 and hydrogens of Amiodarone as well as between hydrogen atom HE1 of M67 and an iodine atom of the drug. Aromatic cage formation is demonstrated by residues F953, Y110, F979, and Y113. These residues are colored purple and show cage formation by aligning their π electrons with Amiodarone.