Figure 3. Effect of FFA1 agonist on duodenal HCO₃⁻ secretion in rats.

Duodenal HCO₃⁻ secretion was measured as total CO₂ output using the flow-through pH and CO₂ electrodes. The duodenal loop was perfused with GW9508 (10 μm). The DPPIV inhibitor NVP728 (NVP) was injected i.v. (3 μmol kg⁻¹) at t = 0 min (A). The GLP-2 receptor antagonist GLP2(3–33) was additionally injected i.v. (3 nmol kg⁻¹, i.v.) at t = 10 min (B). Each data point represents the mean ± SEM (n = 6 rats). *P < 0.05 vs. pH 7.0 Krebs group. ^†P < 0.05 vs. vehicle i.v. + GW9508 group.