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. Author manuscript; available in PMC: 2015 Feb 11.
Published in final edited form as: J Alzheimers Dis. 2012;31(0 3):S169–S188. doi: 10.3233/JAD-2012-120412

Fig. 5.

Fig. 5

General flowchart for the construction of population-specific brain template using LONI pipeline [8, 36]. At first, brain MRI images of the subjects of a population acquired in the DICOM format are converted to ANALYZE image format. Image pre-processing steps include the skull stripping and reorientation of the brain MRI images. The construction protocol includes mainly three steps: The averaged raw brain template is constructed first (red block will be in red color), to which each individual brain MRI image is linearly registered (to account for global shape and intensity differences) to get an averaged linear brain template (the color of green block would be in green color). This is followed by a non-linear registration (to account for local deformations) of each individual brain MRI images to the averaged linear brain template to get averaged non-linear brain template (Blue block will be in blue color).