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. Author manuscript; available in PMC: 2015 Feb 11.
Published in final edited form as: J Alzheimers Dis. 2012;31(0 3):S169–S188. doi: 10.3233/JAD-2012-120412

Table 1.

Different characteristic features (e.g., number of subjects, registration procedure involved, type of spatial transformation used, coverage area, cortical detail etc.) used to construct the existing human brain templates

Feature Talairach
Tournoiix(TT)
(1988)
MNI-305

(1995)
Colin-27

(1998)
MM-152

(2001)
ICBM-452

(2003)
Korean

(2005)
French

(2009)
Chinese-56

(2010)
No. of subjects 1
F-l
305
M-239, F-66
1
M-l
152
NA
452
NA
78
M-49, F-29
1
M-1
56
M-56
Age (years) 60 23.4 ± 4.1 NA NA NA 44.6 ± 19.4 45 24.49 ± 1.76
Image type 2D 3D 3D 3D 3D 3D 3D 3D
Population specific No Yes No Yes Yes Yes Yes Yes
Type of atlas Non-digital Digital Digital Digital Digital Digital Digital Digital
Registration procedure Manual (Intra-subject) Linear (Inter-subject) Linear & non-Linear (Intra-subject) Linear & non-Linear (Inter-subject) Linear & non-Linear (Inter-subject) Linear & non-Linear (Inter-subject) Linear & non-Linear (Inter-subject) Linear & non-Linear (Inter-subject)
Spatial transformation NA 9-parameter Linear Affine 9-parameter Affine 12-parameter Affine Affine Affine 12-parameter Affine
Coverage Excludes brain stem & cerebellum Does not fully cover top of head & cerebellum Full head & cerebellum Full head & cerebellum Full head & cerebellum Full head & cerebellum Deep brain regions Full head & cerebellum
Cortical detail information Lack of cortical detail Lack of cortical detail Improved cortical details Lack of cortical detail Improved cortical detail Improved cortical detail Improved cortical detail Improved cortical detail
Contrast between gray and white matter Less Significant Significant Significant Significant Significant Significant Significant Significant
Size (Length, width & height of brain) Smaller than other brain templates Larger than Talairach Tournoux Same as MNI-305 Same as MNI-305 Same as MNI-305 Height is shorter than IT and MNI-305 but width is same Voxel size reduced Length and height are shorter than MNI-152 but width is more