Table 1. Baseline echocardiographic data of TG and NTG mice.
| Parameters | NTG, 2 month | TG, 2 month | NTG, 6 month | TG, 6 month |
|---|---|---|---|---|
| DSEPWT, mm | 0.82±0.05 | 0.93±0.03 | 0.92±0.07 | 1.1±0.07 |
| LVEDD, mm | 3.76±0.15 | 3.76±0.05 | 3.54±0.1 | 3.52±0.24 |
| DPWT, mm | 0.69±0.02 | 0.79±0.04 | 0.95±0.1 | 1.15±0.08 |
| SSEPWT, mm | 1.11±0.03 | 1.3±0.08 | 1.27±0.11 | 1.58±0.07 |
| LVESD, mm | 2.41±0.11 | 2.48±0.05 | 2.48±0.09 | 2.19±0.16 |
| SPWWT, mm | 0.9±0.04 | 1.05±0.03* | 1.26±0.11 | 1.48±0.11* |
| EF, % | 74±1 | 71±1 | 66±2 | 76±1** |
| FS, % | 36±1 | 34±1 | 30±1 | 38±1** |
| HR, bpm | 417±17 | 359±17 # | 444±24 | 415±59 |
| LA Diameter, mm | 2.2 ± 0.05 | 2.8 ± 0.33 | 1.9 ± 0.1 | 3.5 ± 0.4** |
| E velocity, cm/s | 68±2 | 69±8 | 58±8 | 68±2 |
| A Velocity, cm/s | 54±3 | 30±8** | 44±6 | 18±3** |
| E/A ratio | 1.3±0.1 | 2.8±1.0 | 1.4±0.1 | 4.4±0.6** |
DSEPWT-diastolic septal wall thickness; LVEDD- left ventricular end diastolic dimension; DPWT- diastolic posterior wall thickness; SSEPWT- systolic septal wall thickness; LVESD-Left ventricular end systolic dimension; SPWWT-systolic posterior wall thickness; EF-ejection fraction; FS-fractional shortening; HR- heart rate; bpm- beats per minute; LA Diameter- left atrial diameter; E velocity- early filling velocity; A velocity- atrial filling velocity. Data are mean ± SEM.
**significantly different from NTG, p<0.005
*significantly different from NTG, p<0.05
n = 5 for 2 month old groups and n = 6 for 6 month old groups
# NTG vs.TG
p = 0.056