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. 2015 Jan 27;12:16. doi: 10.1186/s12974-015-0234-7

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© Xu et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Pial arteriolar dilating reponses. Animals were treated with vehicle or FTY720 (0.5 mg/kg) 3 hours post-surgery. Measurements were done at 48 hours after. Compared to SAH-vehicle, SAH-FTY720 animals had improved pial arteriolar vasodilating responses to all the vasodilators tested. (A) hypercapnia (PaCO₂ at approximately 70 mmHg) (P < 0.001). (B) acetylcholine, Ach (*P = 0.003; **P = 0.002). (C) adenosine, ADO (*P = 0.002; **P < 0.001). (D) S-nitroso-N-acetyl penicillamine, SNAP (*P = 0.007; **P < 0.001). Bars represent means ± SEM. n = 5 to 6 each group. Significance was determined using ANOVA.