Table 3.
Association between TOP2A overexpression and other variables.
| Variables | TOP2A overexpression† | P * | |
|---|---|---|---|
| Negative (IHC < 10%) |
Positive (IHC ≥ 10%) |
||
| Tissues | |||
| Nontumors | 40 (100%) | 0 (0%) | <0.001 |
| Tumors | 11 (27.5%) | 29 (72.5%) | |
| Age | |||
| <50 | 4 (22.2%) | 14 (77.8%) | 0.499 |
| ≥50 | 7 (31.8%) | 15 (68.2%) | |
| Tumor size | |||
| <5 cm | 11 (78.6%) | 3 (21.4%) | 0.528 |
| ≥5 cm | 18 (69.2%) | 8 (30.8%) | |
| AFP | |||
| <500 | 7 (29.2%) | 17 (70.8%) | 0.919 |
| ≥500 | 4 (30.8%) | 9 (69.2%) | |
| HBsAg | |||
| Negative | 7 (58.3%) | 5 (41.7%) | 0.004 |
| Positive | 4 (14.3%) | 24 (85.7%) | |
| TP53 expression | |||
| Negative | 7 (33.3%) | 14 (66.7%) | 0.442 |
| Positive | 4 (22.2%) | 14 (77.8%) | |
| Ki-67 expression | |||
| <10% | 5 (55.6%) | 4 (44.4%) | 0.038 |
| ≥10% | 6 (20.0%) | 24 (80.0%) | |
| CEP17 copy number | |||
| <3 copy | 2 (25.0%) | 6 (75.0%) | 1.000 |
| ≥3 copy | 3 (25.0%) | 9 (75.0%) | |
| TOP2A copy number | |||
| <3 copy | 1 (16.7%) | 5 (83.3%) | 1.000 |
| ≥3 copy | 4 (28.6%) | 10 (71.4%) | |
TOP2A overexpression = TOP2A (IHC) ≥10%.
†Result given as n (%).
*Chi-square (χ 2) test.