Table 2.
Concentration (pg/μg protein) of different cytokines in keratoconus keratocyte cultures twenty-four hours after treatment.
Keratocytes | Keratocytes + riboflavin | Keratocytes + 370 nm | Keratocytes + riboflavin + 370 nm | * P value | ** P value | *** P value | |
---|---|---|---|---|---|---|---|
FGFb | 1.1 ± 0.36 | 2.26 ± 1.3 | 1.09 ± 0.36 | 2.88 ± 2.53 | 0.12 | 0.75 | 0.3 |
HGF | 3.94 ± 0.8 | 4.39 ± 0.77 | 3.72 ± 0.26 | 4.28 ± 0.71 | 0.35 | 0.35 | 0.6 |
TGFβ1 | 4.66 ± 0.1 | 4.62 ± 0.46 | 4.62 ± 0.4 | 4.43 ± 0.44 | 0.6 | 0.92 | 0.12 |
VEGF | 12.75 ± 2.01 | 16.02 ± 4.82 | 11.7 ± 2.47 | 14.92 ± 3.8 | 0.18 | 0.35 | 0.25 |
KGF | n.d. | n.d. | n.d. | n.d. | n/a | n/a | n/a |
IL-1β | n.d. | n.d. | n.d. | n.d. | n/a | n/a | n/a |
IL-6 | 0.31 ± 0.16 | 0.45 ± 0.26 | 0.29 ± 0.17 | 0.37 ± 0.15 | 0.53 | 0.6 | 0.75 |
IL-8 | 8.95 ± 2.64 | 8.11 ± 2.41 | 9.43 ± 2.79 | 7.52 ± 1.59 | 0.47 | 0.92 | 0.35 |
Values indicate mean ± SD.
* P values indicate the difference between “keratocytes” versus “keratocytes + 370 nm” groups (Mann-Whitney U test).
** P values indicate the difference between “keratocytes” versus “keratocytes + riboflavin” groups (Mann-Whitney U test).
*** P values indicate the difference between “keratocytes” versus “keratocytes + riboflavin + 370 nm” groups (Mann-Whitney U test).
n.d. = not detectable.
n/a = not applicable.