Table 2.

Summary of statistical tests performed.

Contribution	Methods	Mixed models	Kinship	Type I error	Power
Balliu et al. [2014]	Two-stage	Yes	Exact	No	No
Chen et al. [2014]	BT, SKAT	Yes	Exact	Q1	MAP4
Hailine et al. [2014]	SMT, T2, CMC	No	Exact, estimated	HTN (sim1)	HTN (sim1)
He and Pitkäniemi [2014]	FBCM	Yes	Family-level indicator	own simulation	own simulation
Lacey et al. [2014]	SMT	Yes	Exact	No	No
Li et al. [2014]	SMT, SKAT	Yes	Estimated	Q1	7 genes
Liu et al. [2014]	T2, CMC	No	Exact	HTN (chromosome 3)	HTN (chromosome 3)
Malzahn et al. [2014]	SKAT	Yes	Exact	Q1	MAP4
Zhang and Pan [2014]	SMT, PCA	Yes	Estimated	SBP, HTN	No

BT, family-based burden test; CMC, family-based combined multivariate and collapsing method; FBCM, family-based Bayesian collapsing method; PCA, principal components analysis; SBP, systolic blood pressure; SKAT, family-based sequence kernel association test; SMT, family-based single marker test.