Table 2.
Sex hormones serum levels in active VKC and healthy subjects.
| Total | Prepubertal | Early pubertal | ||||
|---|---|---|---|---|---|---|
| VKC | Healthy | VKC | Healthy | VKC | Healthy | |
| N | 19 | 36 | 12 | 20 | 7 | 16 |
| Age | ||||||
| Mean ± SD | 8.7 ± 2 | 8.5 ± 2.9 | 7.3 ± 0.9 | 7 ± 1.3 | 11 ± 0.7 | 11 ± 1.1 |
| Range | 6–12 | 6–13 | 6–9 | 6–9 | 9–12 | 9–13 |
| LH (mUI/mL) | ||||||
| Mean ± SD | 0.5 ± 0.3 | 0.6 ± 0.5 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.9 ± 0.5 | 0.8 ± 0.5 |
| Range | 0.2–1.2 | 0.1–2 | 0.2–0.7 | 0.1–0.8 | 0.5–1.2 | 0.1–2 |
| FSH (mUI/mL) | ||||||
| Mean ± SD | 0.7 ± 0.5* | 1.4 ± 0.7 | 0.6 ± 0.4 | 1 ± 0.6 | 0.8 ± 0.6* | 1.8 ± 0.8 |
| Range | 0.3–1.7 | 0.2–4 | 0.3–1.2 | 0.2–3 | 0.3–1.7 | 0.6–4 |
| Total testosterone (ng/100 mL) | ||||||
| Mean ± SD | 28.7 ± 47 | 18 ± 12 | 13 ± 9.1 | 9.8 ± 4.2 | 36 ± 24 | 26 ± 12 |
| Range | 1–73 | 4–48 | 1–27 | 4–17 | 7–73 | 6–48 |
| Free testosterone (ng/100 mL) | ||||||
| Mean ± SD | 2.7 ± 4.7* | 1 ± 1 | 2 ± 2.8* | 0.4 ± 0.1 | 4.1 ± 7.4 | 1.6 ± 1 |
| Range | 0.5–19.2 | 0.2–4.9 | 0.5–8.6 | 0.2–0.5 | 0.5–19.2 | 0.2–4.9 |
| DHT (pg/mL) | ||||||
| Mean ± SD | 17 ± 11.7 | 41.7 ± 36.3 | 15 ± 8.7* | 21 ± 4 | 21 ± 19* | 64 ± 43 |
| Range | 3–38 | 15–140 | 3–25 | 15–27 | 1.3–38 | 20–140 |
| Estradiol (pg/mL) | ||||||
| Mean ± SD | 14.7 ± 6.8 | 17.7 ± 5.5 | 14.9 ± 7.2 | 17.4 ± 4.9 | 14.2 ± 6.7 | 17.9 ± 6 |
| Range | 5–29 | 10–34 | 5–29 | 10–27 | 10–24 | 10–34 |
| Estrone (pg/mL) | ||||||
| Mean ± SD | 33.8 ± 18.8* | 12.8 ± 2.4 | 33.7 ± 3.5* | 12 ± 1.7 | 34.5 ± 3.5* | 16.5 ± 1.9 |
| Range | 10–64 | 10–18 | 10–64 | 10–15 | 32–37 | 14–18 |
| DHEAS (ng/mL) | ||||||
| Mean ± SD | 855 ± 1008 | 612 ± 221 | 707 ± 685 | 488 ± 186 | 1111 ± 1440 | 731 ± 186 |
| Range | 87–2640 | 132–1200 | 87–2190 | 132–861 | 273–2640 | 358–1200 |
| D4A (ng/mL) | ||||||
| Mean ± SD | 0.7 ± 0.7 | 0.7 ± 0.3 | 0.7 ± 0.8 | 0.5 ± 0.2 | 0.9 ± 0.4 | 0.9 ± 0.4 |
| Range | 0.1–2.5 | 0.3–2.2 | 0.1–2.5 | 0.3–0.9 | 0.6–1.2 | 0.6–2.2 |
| Cortisol (ng/mL) | ||||||
| Mean ± SD | 122 ± 73 | 102 ± 49 | 138 ± 80 | 107 ± 55 | 79 ± 28 | 96 ± 41 |
| Range | 31–238 | 35–205 | 31–238 | 35–205 | 51–107 | 45–197 |
| SHBG (nmol/L) | ||||||
| Mean ± SD | 65.9 ± 41 | 120 ± 19* | 76.6 ± 42.6* | 110.5 ± 28 | 41.7 ± 25* | 134 ± 49 |
| Range | 21–164 | 49–208 | 40–164 | 84–208 | 21–78 | 49–206 |
VKC: vernal keratoconjunctivitis; * P < 0.05; N: number; SD: standard deviation; LH: luteinizing hormone; FSH: follicle-stimulating hormone; DHT: dihydrotestosterone; DHEAS: dehydroepiandrosterone-sulfate; D4A: delta-4-androstenedione; SHBG: sex hormones binding globulin.