FIG 1.

Schematic representation of ftpA, its genetic environment in A. fumigatus, and the domain arrangement of the gene product. Introns are not shown. Gene Afu3g15250 putatively encodes a transporter of the major facilitator superfamily, gene Afu3g15260 encodes a hypothetical protein, the ftpA gene encodes the fumaryl-l-tyrosine/fumaryl-l-phenylalanine synthetase (Afu3g15280), a methyltransferase, and ftpR, a Zn₂Cys₆ transcription factor. Abbreviations for synthetase domains: A, adenylation; T, thiolation; C, condensation. The chemical structures of compounds 1 and 2 are shown below the enzyme.