Fig. 2.

Effect of subchronic administration of imperatorin (IMP; 1, 5, or 10 mg/kg) on the memory acquisition trial (a) or consolidation trial (b) induced by scopolamine (SCP; 1 mg/kg), using the PA test in mice. Imperatorin (1, 5, or 10 mg/kg) or saline was administered for 6 days, twice daily. On the seventh day, appropriate group of mice received saline, imperatorin (1, 5, or 10 mg/kg, i.p.), or scopolamine (1 mg/kg, i.p.), coadministered with saline or scopolamine (1 mg/kg, i.p.) before the pretest (a) or immediately after the pretest (b). Data represent the means ± SEM and are expressed as latency index (IL); n = 8–12; the means ± SEM; ^# p < 0.05, ^## p < 0.01, ^### p < 0.001 versus saline-treated control group; *p < 0.05, **p < 0.01 versus scopolamine-treated control group; Tukey’s test